{"product_id":"how-new-one-week-oral-glpi-is-developed-ind","title":"How the New Once a-Week Oral GLPI is Developed-IND","description":"\u003cdiv\u003e\n\u003cdiv\u003e\u003cb data-olk-copy-source=\"MailCompose\"\u003eSummary of our current one-week oral GLP-1 is an IND under development. This is for informational and research purposes only.\u003c\/b\u003e\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cb data-olk-copy-source=\"MailCompose\"\u003e\u003c\/b\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cb data-olk-copy-source=\"MailCompose\"\u003e\u003c\/b\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003cul data-editing-info='{\"applyListStyleFromLevel\":true}'\u003e\n\u003cli\u003e\n\u003cdiv role=\"presentation\"\u003eThe API is modified to resist rapid degradation by the DPP-4 enzyme.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cul data-editing-info='{\"applyListStyleFromLevel\":true}'\u003e\n\u003cli\u003e\n\u003cdiv role=\"presentation\"\u003eWe replace the naturally occurring alanine at position 8 with a non-natural amino acid.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003e\n\u003cul data-editing-info='{\"applyListStyleFromLevel\":true}'\u003e\n\u003cli\u003e\n\u003cdiv role=\"presentation\"\u003eStructural constraints are introduced to stabilize the alpha-helix structure of the peptide, which increases receptor binding affinity and further protects against enzymatic breakdown.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul data-editing-info='{\"applyListStyleFromLevel\":true}'\u003e\n\u003cli\u003e\n\u003cdiv role=\"presentation\"\u003eA \"tail\" is attached that binds reversibly to human serum albumin\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv role=\"presentation\"\u003eNext-generation transient permeability enhancers (TPE) or cell-penetrating peptides (CPPs) are added to increase bioavailability from ~1% offered by SNAC up to 5-10%.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul data-editing-info='{\"applyListStyleFromLevel\":true}'\u003e\n\u003cli\u003e\n\u003cdiv role=\"presentation\"\u003eSpecific enzyme inhibitors are added to neutralize digestive enzymes in the immediate vicinity of the dissolving pill.\u003c\/div\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cdiv role=\"presentation\"\u003eTablets are enterically coated to target absorption in the small intestine rather than the stomach\u003c\/div\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eContact us for details of the current stage of R\u0026amp;D for this masterpiece development. \u003cstrong\u003eObjective: \u003c\/strong\u003eTo enhance consumers' experience and wellness from weekly injection pain to weekly painless comfort.\u003c\/p\u003e\n\u003cp\u003eZeptide Pharma is a pioneering biotechnology company leading the transition from injectable metabolic therapies to highly effective, patient-friendly oral treatments. We are the premier developer of the \u003cstrong\u003enext-generation GLP-1 pill\u003c\/strong\u003e, engineered to deliver powerful metabolic control and weight management in a convenient \u003cstrong\u003eonce-weekly weight loss pill\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003eBy utilizing our proprietary \u003cstrong\u003ealbumin-binding peptide formulation\u003c\/strong\u003e alongside advanced permeation enhancers, we have solved the historic challenges of oral peptide delivery. Our flagship \u003cstrong\u003eoral GLP-1 tablet\u003c\/strong\u003e provides the extended half-life and sustained efficacy of traditional injectables, all within a single weekly dose.\u003c\/p\u003e\n\u003cp\u003eAt Zeptide Pharma, our mission is to redefine obesity and diabetes care by delivering the ultimate \u003cstrong\u003eno-injection weight loss medication\u003c\/strong\u003e. As a leader in \u003cstrong\u003eoral GLP-1 receptor agonist\u003c\/strong\u003e research, we are dedicated to improving patient compliance, expanding treatment accessibility, and shaping the future of long-acting oral therapeutics.\u003c\/p\u003e\n\u003c\/div\u003e","brand":"AmWiners","offers":[{"title":"Default Title","offer_id":48911430811956,"sku":null,"price":1.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1300\/5889\/files\/Novo_semaglutide_pills.png?v=1790786719","url":"https:\/\/tirzeptide.com\/products\/how-new-one-week-oral-glpi-is-developed-ind","provider":"Zeptide Pharma","version":"1.0","type":"link"}