Our mission is to create better health for all. We do not offer just acetaminophen pain relief; we conjugate this compound with glutathione and N-acetylcysteine. In the reaction vessel, acetaminophen (APAP) reacts with glutathione GSH to form a conjugate called acetaminophen-glutathione conjugate APAP-GSH, forming a key detoxification pathway for APAP and its toxic metabolite NAPQI.  

When APAP is metabolized in the liver, it can form a toxic metabolite called N-acetyl-p-benzoquinone imine (NAPQI). NAPQI is highly reactive and can cause liver damage. To prevent this damage, NAPQI can bind to GSH, a naturally occurring molecule in the body, to form APAP-GSH. This reaction is catalyzed by enzymes called glutathione-S-transferases (GSTs.

GSH is essential for detoxifying reactive metabolites, including NAPQI. APAP-GSH is metabolized and excreted in the urine, primarily as cysteine and N-acetylcysteine conjugates. NAC is a cysteine prodrug used as an antidote for APAP overdose because it helps replenish GSH levels and can also bind directly to NAPQI. 

MQTY: 3.5M caplets

Contact us for pricing